티타늄합금 번역

티타늄합금 번역(한국어 원본)

Bioactive ceramics를 implant에 코팅하여 골과의 osseointegration을 높인다는 보고가 있으나 티타늄 합금 cancellous screw에서 bioactive ceramics coating이 osseointegration에 미치는 영향에 대해서는 알려진 바 없다. 이에 저자들은 티타늄 합금 cancellous screw (Solco, 18mm)에 β-calcium pyrophosphate (CPP)과 bioactive glass-ceramics인 CaO-SiO₂-B₂O₃ glass-ceramics (CSG), apatite-wollastonite 1:3 glass-ceramics (W3G), 그리고, CaO-SiO₂-P₂O₅-B₂O₃ glass-ceramics (BGS-7)를 enameling method로 코팅한 후 코팅하지 않은 나사못과 함께 30-35kg 수컷 mongrel dog 7마리의 양측 metaphysic of the proximal tibia and distal femur에 삽입하고 8주 생육 후 bone-implant 계면에 대해 나사못 제거시의 토크값과 cancellous bone 부분에 대해 나사못의 골에 직접 결합한 bone의 분율을 histomorphometry로 분석하였다. 5종류의 나사못에 대해 삽입시 토크값에는 유의한 차이가 없었으나 8주 후 제거시 토크값은 CPP와 BGS-7을 코팅한 군이 각각의 삽입시 토크값과 8주 후의 코팅하지 않은 나사못에 비해 유의하게 높았다. 또, 0000 조직학 슬라이드에서 나사골에서 골과 접한 분율에서 cortical bone 부분은 CPP, W3G, BGS-7이 코팅하지 않은 나사못에 비해 모두 유의하게 높았고, cancellous bone 부분은 CPP와 BGS-7이 uncoated screw에 비해 유의하게 높았다. CPP와 BGS-7을 코팅할 경우 cancellous bone부분에 골과 직접 결합함으로써 osseointegration이 증가하므로 고정력이 약한 부분에 대한 indication을 넓힐 수 있을 것으로 판단된다.

티타늄합금 번역(영어 번역본)

There have been reports on improving osseointegration in bones by coating implants with bioactive ceramics, but the effects of bioactive ceramic coating on osseointegration in titanium alloy cancellous screws are not yet known. Accordingly, the authors of this paper coated titanium alloy cancellous screws (Solco, 18mm) with β-calcium pyrophosphate (CPP) and bioactive glass-ceramics (CaO-SiO₂-B₂O₃ glass-ceramics (CSG), apatite-wollastonite 1:3 glass-ceramics (W3G), and CaO-SiO₂-P₂O₅-B₂O₃ glass-ceramics (BGS-7)) by the enameling method, and these coated screws as well as the uncoated screws were inserted into the metaphysic of the proximal tibia and distal femur of 7 male mongrel dogs weighing between 30 to 35kg.  After the 8-week raising period, the torque values at the time of screw removal from bone-implant interface and the fraction of bone directly bonded to bone screw have been analyzed by histomorphometry.     There was no significant difference in insertion torques of 5 types of screws but as for the removal torques measured after 8 weeks, the insertion torques of groups coated with CPP and BGS-7 were significantly higher than the value of uncoated screw measured after 8 weeks. Also, the histological slide of 0000 showed that the fraction of screw-bone interface in the cortical bone area was significantly higher for CPP, W3G and BGS-7 than the uncoated screw, and in the cancellous bone area, CPP and BGS-7 were higher than the uncoated screw.  Osseointegration is improved when the screws coated with CPP and BGS-7 directly bond with the bone in the cancellous bone area, and thus may broaden the indications for the areas with poor fixation.  

The coating layer obtained from coating CPP and BGS-7 directly bonds with cancellous bone to improve osseointegration, thus the coating method may broaden indication even in the case of poor bone quality.